One of the most intriguing questions in consciousness research today is how brain chemistry might connect with the kinds of anomalies we see in random data experiments – the kind of patterns our Wyrdoscope and Wyrd Light are designed to detect.
A key player here is GABA – gamma-aminobutyric acid – the brain’s main inhibitory neurotransmitter. Put simply, GABA acts like the brain’s brake system. When GABA levels are high, neural activity is calmed and regulated. When GABA is low, the brakes come off, and the brain enters more excitable, less inhibited states.
Why does this matter?
Recent neuroscience suggests that when the brain’s usual executive controls relax, unusual things can happen. A study published earlier this year (Freedman et al., 2025) found that temporarily reducing frontal-lobe activity actually increased the strength of mind–matter correlations in a laboratory setting. In other words, the brain became more open to subtle patterns that don’t fit ordinary causal explanations – much like the anomalies we see in random event generators during moments of coherence.
This resonates with insights from Walter von Lucadou’s Model of Pragmatic Information (MPI), which argues that anomalies arise not as signals but as entanglement correlations in systems that become temporarily closed and self-organising – such as a group ritual, a deep meditation, or a shared emotional peak. If GABA is one of the brain’s main brakes, then lowering GABA could allow these entanglement effects to manifest more strongly.
But it’s not so simple. Stress, sleep deprivation, or too much coffee also reduce GABA – and no one thinks those are ideal conditions for PSI. The difference seems to lie in how inhibition is reduced. When frontal control networks are quietly disengaged – as in trance, dreaming, or deep relaxation – the system may become more coherent, opening the door to non-local correlations. When GABA is low because of stress or over-stimulation, the system becomes fragmented instead, and coherence collapses.
The idea is also showing up in popular culture. Dan Brown’s new novel The Secret of Secrets explores the role of GABA in altered states of consciousness – from dreams to near-death experiences and out-of-body journeys. In that liminal zone where the ordinary mind lets go, different kinds of patterns seem to emerge.
Could it be that low GABA states – whether in dreams, death, or deep trance – make us more permeable to hidden connections, and that these show up as anomalies in Wyrd data streams? It’s too early to say for sure, but the hypothesis is tantalising.
What would it mean to test this? Future research could combine brain chemistry measures (like GABA levels measured through neuroimaging) with Wyrdoscope recordings to see if there’s a systematic relationship. If the connection proves real, we may be on the edge of linking neurobiology with the physics of meaning.
For now, the question remains open – but it’s one worth asking:
Are the brain’s inhibitory brakes also what keep us insulated from the deeper patterns of reality?
References and Further Reading
- Freedman, D. et al. (2025). Inhibiting frontal activity via rTMS enhances mind–matter correlations. [Abstract presented at the Parapsychological Association Convention.]
- von Lucadou, W. (1995, 2015). The Model of Pragmatic Information (MPI). In: May, E.C. & Marwaha, S. (Eds.), Extrasensory Perception: Support, Skepticism, and Science. Praeger.
- Römer, H., von Lucadou, W., & Walach, H. (2007). Synchronistic phenomena as entanglement correlations in generalized quantum theory. Journal of Consciousness Studies, 14(4), 50–74.
- Nelson, R. et al. (2002). Correlations of continuous random data with major world events. Foundations of Physics Letters, 15(6), 537–550.
- Brown, D. (2025). The Secret of Secrets. Penguin Random House.